Apparatus for Continuous Infusion Chemotherapy

Transporting patients receiving continuous infusion chemotherapy.

A nswer: The rationale for CI chemotherapy is based on the physiology of the cell cycle and pharmacokinetics of chemotherapy agents. Because only a fraction of cancer cells are cycling actively at a given point in time, prolonged infusion of chemotherapy increases the amount of exposure of the cancer cells to the chemotherapy. Also, because many chemotherapy agents have short plasma half-lives,...

Combination chemotherapy with navelbine and continuous infusion of 5-fluorouracil in metastatic, chemotherapy refractory breast cancer.

BACKGROUND The protracted continuous infusion (PCI) of 5-fluorouracil (5-FU) has proven in several studies an active and well tolerated treatment for advanced, pretreated breast cancer. Navelbine has also activity in this setting. PATIENTS AND METHODS Heavily pretreated patients with metastatic breast carcinoma were eligible for the study. Treatment consisted of 5-FU 250 mg/m2 given as a PCI ...

Hepatic Artery Infusion Chemotherapy

Hepatic artery chemotherapy was given to 36 patients, using totally implantable devices consisting of a port and external pump. Twenty-seven patients had inoperable liver metastases of colorectal origin. The infusion system was inserted by laparotomy into the hepatic artery via the gastroduodenal artery. There was no operative mortality. Thirteen infusion systems could not be used for chemother...

Continuous-Culture Apparatus for Long-Term Use1

The continuous production and harvest of uncontaminated cells for periods of several months are a major requirement inthe design of a suitable culture system. Many continuous-culture units have been reported previously (1, 2), and some units are now commercially available. However, in these units, rubber, metals, and other sources of potentially toxic extractives are not prevented from direct c...

An Apparatus for Continuous Oiling of Streams